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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
O75608
USC-OGP 2-DE database
:
O75608
O75608
General information about the entry
View entry in simple text format
Entry name
O75608
Primary accession number
O75608
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Acyl-protein thioesterase 1; Short=APT-1; Short=hAPT1; EC=3.1.2.-; AltName: Full=Lysophospholipase 1; AltName: Full=Lysophospholipase I; Short=LPL-I; Short=LysoPLA I;.
Gene name
Name=LYPLA1
Synonyms=APT1, LPL1
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-7
{PLATELET 4-7}
Homo sapiens (Human)
map experimental info
PLATELET_4-7
MAP LOCATIONS:
SPOT OGP-0545
:
pI=6.10; Mw=23617
PLATELET_6-11
{PLATELET 6-11}
Homo sapiens (Human)
map experimental info
PLATELET_6-11
MAP LOCATIONS:
SPOT OGP-1022
:
pI=6.06; Mw=23958
SPOT OGP-1023
:
pI=6.10; Mw=23680
Cross-references
UniProtKB/Swiss-Prot
O75608; LYPA1_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
LYPA1_HUMAN
Primary accession number
O75608
Secondary accession number(s)
O43202 Q9UQF9
Sequence was last modified on
November 1, 1998 (version 1)
Annotations were last modified on
March 15, 2017 (version 156)
Name and origin of the protein
Description
RecName: Full=Acyl-protein thioesterase 1; Short=APT-1; Short=hAPT1; EC=3.1.2.-; AltName: Full=Lysophospholipase 1; AltName: Full=Lysophospholipase I; Short=LPL-I; Short=LysoPLA I;
Gene name
Name=LYPLA1
Synonyms=APT1, LPL1
Encoded on
Name=LYPLA1; Synonyms=APT1, LPL1
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
Complete proteome
;
Cytoplasm
;
Fatty acid metabolism
;
Hydrolase
;
Lipid metabolism
;
Polymorphism
;
Reference proteome
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
AF081281; AAC31610.1
; -; mRNA
EMBL
AF291053; AAG10063.1
; -; mRNA
EMBL
AF077198; AAD26993.1
; -; mRNA
EMBL
AF077199; AAD26994.1
; -; mRNA
EMBL
BC008652; AAH08652.1
; -; mRNA
EMBL
BC010397; AAH10397.1
; -; mRNA
EMBL
AF035293; AAB88180.1
; ALT_INIT; mRNA
CCDS
CCDS6157.1; -. [O75608-1]
; .
CCDS
CCDS64899.1; -. [O75608-2]
; .
RefSeq
NP_001266285.1; NM_001279356.1
; .
RefSeq
NP_001266286.1; NM_001279357.1. [O75608-2]
; .
RefSeq
NP_001266287.1; NM_001279358.1
; .
RefSeq
NP_001266288.1; NM_001279359.1
; .
RefSeq
NP_001266289.1; NM_001279360.1
; .
RefSeq
NP_006321.1; NM_006330.3. [O75608-1]
; .
UniGene
Hs.744046; -
; .
PDB
1FJ2; X-ray
; 1.50 A; A/B=6-230
PDB
5SYM; X-ray
; 1.55 A; A/B=1-230
PDBsum
1FJ2; -
; .
PDBsum
5SYM; -
; .
ProteinModelPortal
O75608; -
; .
SMR
O75608; -
; .
BioGrid
115701; 22
; .
IntAct
O75608; 4
; .
MINT
MINT-5005801; -
; .
STRING
9606.ENSP00000320043; -
; .
BindingDB
O75608; -
; .
ChEMBL
CHEMBL1681631; -
; .
SwissLipids
SLP:000000734; -
; .
ESTHER
human-LYPLA1; LYsophospholipase_carboxylesterase
; .
MEROPS
S09.941; -
; .
iPTMnet
O75608; -
; .
PhosphoSitePlus
O75608; -
; .
SwissPalm
O75608; -
; .
BioMuta
LYPLA1; -
; .
OGP
O75608; -
; .
EPD
O75608; -
; .
PaxDb
O75608; -
; .
PeptideAtlas
O75608; -
; .
PRIDE
O75608; -
; .
DNASU
10434; -
; .
Ensembl
ENST00000316963; ENSP00000320043
; ENSG00000120992. [O75608-1]; .
Ensembl
ENST00000343231; ENSP00000344477
; ENSG00000120992. [O75608-2]; .
GeneID
10434; -
; .
KEGG
hsa:10434; -
; .
UCSC
uc003xrz.5; human. [O75608-1]
; .
CTD
10434; -
; .
DisGeNET
10434; -
; .
GeneCards
LYPLA1; -
; .
HGNC
HGNC:6737; LYPLA1
; .
HPA
HPA050941; -
; .
HPA
HPA063151; -
; .
MIM
605599; gene
; .
neXtProt
NX_O75608; -
; .
OpenTargets
ENSG00000120992; -
; .
PharmGKB
PA30499; -
; .
eggNOG
KOG2112; Eukaryota
; .
eggNOG
COG0400; LUCA
; .
GeneTree
ENSGT00390000009648; -
; .
HOGENOM
HOG000260139; -
; .
HOVERGEN
HBG052378; -
; .
InParanoid
O75608; -
; .
KO
K06128; -
; .
OMA
VEWHEYS; -
; .
OrthoDB
EOG091G080L; -
; .
PhylomeDB
O75608; -
; .
TreeFam
TF314619; -
; .
BRENDA
3.1.2.22; 2681
; .
Reactome
R-HSA-203615; eNOS activation
; .
ChiTaRS
LYPLA1; human
; .
EvolutionaryTrace
O75608; -
; .
GeneWiki
LYPLA1; -
; .
GenomeRNAi
10434; -
; .
PRO
PR:O75608; -
; .
Proteomes
UP000005640; Chromosome 8
; .
Bgee
ENSG00000120992; -
; .
CleanEx
HS_LYPLA1; -
; .
ExpressionAtlas
O75608; baseline and differential
; .
Genevisible
O75608; HS
; .
GO
GO:0005737; C:cytoplasm
; IBA:GO_Central; .
GO
GO:0005829; C:cytosol
; TAS:Reactome; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005739; C:mitochondrion
; IEA:Ensembl; .
GO
GO:0016298; F:lipase activity
; IDA:CACAO; .
GO
GO:0004622; F:lysophospholipase activity
; TAS:ProtInc; .
GO
GO:0008474; F:palmitoyl-(protein) hydrolase activity
; IMP:UniProtKB; .
GO
GO:0006631; P:fatty acid metabolic process
; IEA:UniProtKB-KW; .
GO
GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport
; IEA:Ensembl; .
GO
GO:0002084; P:protein depalmitoylation
; IBA:GO_Central; .
GO
GO:0050999; P:regulation of nitric-oxide synthase activity
; TAS:Reactome; .
Gene3D
3.40.50.1820; -
; 1; .
InterPro
IPR029058; AB_hydrolase
; .
InterPro
IPR003140; PLipase/COase/thioEstase
; .
Pfam
PF02230; Abhydrolase_2
; 1; .
SUPFAM
SSF53474; SSF53474
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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